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While the specific mechanism causing the effects on the gastrointestinal tract are not fully elucidated, studies suggest GLP-1 and its analogues likely exert effects on the vagus nerve and inhibit cholinergic neurotransmission in the gastrointestinal system to prevent movement of the intestine

Interactions With Growth Factors By modulating growth factors like VEGF, BPC 157 encourages new capillary networks in injured areas

doi: 10.1073/pnas.0605374104 14 BadmusO

This may suggest the possibility that the short-acting nature of GLP-1 activation enhancement was insufficient to reduce the occurrence of CV events, beyond improved glycemic metabolism